The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
G Hoxhaj, BD Manning - Nature Reviews Cancer, 2020 - nature.com
The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation
and survival. In normal cells, signal transduction pathways control core cellular functions, …
and survival. In normal cells, signal transduction pathways control core cellular functions, …
Interventions to address mental health issues in healthcare workers during infectious disease outbreaks: a systematic review
D Zaçe, I Hoxhaj, A Orfino, AM Viteritti, L Janiri… - Journal of psychiatric …, 2021 - Elsevier
Considering the importance of evidence on interventions to tackle mental health problems
in healthcare workers (HCWs) during pandemics, we conducted a systematic review, aiming …
in healthcare workers (HCWs) during pandemics, we conducted a systematic review, aiming …
[HTML][HTML] Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
mTORC1 promotes cell growth in response to nutrients and growth factors. Insulin activates
mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex (…
mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex (…
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates
anabolic processes underlying cell growth. We found that mTORC1 increases metabolic …
anabolic processes underlying cell growth. We found that mTORC1 increases metabolic …
[PDF][PDF] Metformin inhibits hepatic mTORC1 signaling via dose-dependent mechanisms involving AMPK and the TSC complex
Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However,
knowledge of the full effects of metformin on biochemical pathways and processes in its …
knowledge of the full effects of metformin on biochemical pathways and processes in its …
Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
Ageing is driven by a loss of transcriptional and protein homeostasis 1 , 2 , 3 and is the key
risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …
risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …
[PDF][PDF] The mTORC1 signaling network senses changes in cellular purine nucleotide levels
Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from
growth factors and nutrients to control biosynthetic processes, including protein, lipid, and …
growth factors and nutrients to control biosynthetic processes, including protein, lipid, and …
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth
Nicotinamide adenine dinucleotide phosphate (NADP + ) is vital to produce NADPH, a
principal supplier of reducing power for biosynthesis of macromolecules and protection against …
principal supplier of reducing power for biosynthesis of macromolecules and protection against …
[HTML][HTML] Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
Purine nucleotides are necessary for various biological processes related to cell proliferation.
Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-…
Despite their importance in DNA and RNA synthesis, cellular signaling, and energy-…
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase
Nicotinamide adenine dinucleotide phosphate (NADP + ) is essential for producing NADPH,
the primary cofactor for reductive metabolism. We find that growth factor signaling through …
the primary cofactor for reductive metabolism. We find that growth factor signaling through …