We examined the effectiveness of antisense RNA (as RNA) strategies for metabolic engineering
of Clostridium acetobutylicum. Strain ATCC 824(pRD4) was developed to produce a 102…

Two metabolic engineering tools, namely gene inactivation and gene overexpression, were
employed to examine the effects of two genetic modifications on the fermentation …

Metabolic flux analysis was used to investigate the roles of the acid formation pathways in
Clostridium acetobutylicum. The acid formation pathways were revealed to serve different …

A stoichiometric model of Clostridium acetobutylicum and related strains has been previously
derived. The stoichiometric matrix of the model contains a singularity which has prevented …

In the last few years, increasing globalization and integration of capital markets have made it
imperative to harmonize accounting standards across the globe. It is becoming very difficult …

Chemobiosynthesis has been used to prepare analogs of erythromycins having unique
functional groups at the 15-position. Using diketide thioester feeding to genetically engineered …

Precursor-directed biosynthesis has been shown to be a powerful tool for the production of
polyketide analogues that would be difficult or cost prohibitive to produce from medicinal …

The bioconversion of a 6‐deoxyerythronolide B analogue to the corresponding erythromycin
A analogue (R‐EryA) by a Saccharopolyspora erythraea mutant lacking the ketosynthase in …

Precursor‐directed biosynthesis was used to produce different triketide lactones (R‐TKLs)
in a fermentation process. Plasmids expressing engineered versions of the first subunit of 6‐…

An exchange-traded fund (ETF) is a financial asset that tracks a chosen index and trades
continuously throughout the day. The price differential between the market price and net asset …