Background The efficacy of interleukin-6 receptor blockade in hospitalized patients with
coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. …

The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a
global health priority. We evaluated the protective activity of a chimpanzee adenovirus-…

Although 20%‐40% of persons with acute hepatitis C virus (HCV) infection demonstrate
spontaneous clearance, the time course and factors associated with clearance remain poorly …

Background: In the EPIC-HR (Evaluation of Protease Inhibition for Covid-19 in High-Risk
Patients) trial, nirmatrelvir plus ritonavir led to an 89% reduction in hospitalization or death …

Resistance mutations to hepatitis C virus (HCV) nonstructural protein 3 (NS3) protease
inhibitors in <1% of the viral quasispecies may still allow >1000‐fold viral load reductions upon …

Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and
possibly transmission. An anticipated correlate of such countermeasures is the level of …

Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully
understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to …

In the setting of acute hepatitis C virus (HCV) infection, robust HCV-specific CD8 + cytotoxic
T lymphocyte (CTL) responses are associated with initial control of viremia. Despite these …

Background & Aims: Cellular immune responses are thought to play a key role in the
resolution of primary HCV infection. Although it has been consistently shown that CD4+ T-cell …