Simulation as an engine of physical scene understanding

PW Battaglia, JB Hamrick… - Proceedings of the …, 2013 - National Acad Sciences
In a glance, we can perceive whether a stack of dishes will topple, a branch will support a
child’s weight, a grocery bag is poorly packed and liable to tear or crush its contents, or a tool …

[HTML][HTML] The senolytic drug navitoclax (ABT-263) causes trabecular bone loss and impaired osteoprogenitor function in aged mice

…, JL Pierce, K Yu, MW Hamrick… - Frontiers in cell and …, 2020 - frontiersin.org
Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but
chronic senescence, as in aging, can contribute to the development of age-related tissue …

Kynurenine, a tryptophan metabolite that accumulates with age, induces bone loss

…, M Hunter, JL Pierce, K Yu, MW Hamrick… - Journal of Bone and …, 2017 - academic.oup.com
Age‐dependent bone loss occurs in humans and in several animal species, including
rodents. The underlying causal mechanisms are probably multifactorial, although an age‐…

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

…, WD Hill, CM Isales, WB Bollag, MW Hamrick… - Experimental …, 2020 - Elsevier
Aging is a progressive process associated with declining tissue function over time.
Kynurenine, an oxidized metabolite of the essential amino acid tryptophan that increases in …

[HTML][HTML] Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal …

…, M Hunter, C Reitman, BF Volkman, MW Hamrick… - Bone reports, 2020 - Elsevier
Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis
are still incompletely understood. We recently demonstrated that kynurenine (KYN), a …

The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat

…, WB Bollag, MH Johnson, MW Hamrick… - Journal of …, 2019 - joe.bioscientifica.com
Excess fat within bone marrow is associated with lower bone density. Metabolic stressors
such as chronic caloric restriction (CR) can exacerbate marrow adiposity, and increased …

The glucocorticoid receptor in osterix‐expressing cells regulates bone mass, bone marrow adipose tissue, and systemic metabolism in female mice during aging

…, MH Johnson, WB Bollag, MW Hamrick… - Journal of Bone and …, 2020 - academic.oup.com
Hallmarks of aging‐associated osteoporosis include bone loss, bone marrow adipose tissue
(BMAT) expansion, and impaired osteoblast function. Endogenous glucocorticoid levels …

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

…, EJ Kennedy, M Elsalanty, MW Hamrick… - Experimental …, 2020 - Elsevier
Tryptophan is an essential amino acid catabolized initially to kynurenine (kyn), an
immunomodulatory metabolite that we have previously shown to promote bone loss. Kyn levels …

Systemic loxoscelism in a nonendemic area: a diagnostic challenge for the unsuspecting physician

…, MM Rusin, MA Bertone, HJ Hamrick - Clinical …, 2014 - journals.sagepub.com
Except for the far western tip, North Carolina is not considered within the ecological range of
brown and other recluse spiders (Loxosceles sp.). 1 All published reports of systemic …

Efficacy of Chest Compressions Directed by End‐Tidal CO2 Feedback in a Pediatric Resuscitation Model of Basic Life Support

JL Hamrick, JT Hamrick, JK Lee, BH Lee… - Journal of the …, 2014 - Am Heart Assoc
Background End‐tidal carbon dioxide ( ETCO 2 ) correlates with systemic blood flow and
resuscitation rate during cardiopulmonary resuscitation ( CPR ) and may potentially direct chest …