Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia
HM Horton, MJ Bernett, E Pong, M Peipp, S Karki… - Cancer research, 2008 - AACR
… Effector cells at an effector to target (E/T) cell ratio of 5:1 were cocultured for 4 h and
lactate dehydrogenase (LDH) activity was measured using the Cytotoxicity Detection kit (CytoTox-…
lactate dehydrogenase (LDH) activity was measured using the Cytotoxicity Detection kit (CytoTox-…
Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies
…, I Vostiar, S Karki, GL Moore, GA Lazar, E Pong… - Molecular …, 2008 - Elsevier
The humoral immune response requires antigen-specific B cell activation and subsequent
terminal differentiation into plasma cells. Engagement of B cell antigen receptor (BCR) on …
terminal differentiation into plasma cells. Engagement of B cell antigen receptor (BCR) on …
Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus
HM Horton, SY Chu, EC Ortiz, E Pong… - The Journal of …, 2011 - journals.aai.org
Engagement of the low-affinity Ab receptor FcγRIIb downregulates B cell activation, and its
dysfunction is associated with autoimmunity in mice and humans. We engineered the Fc …
dysfunction is associated with autoimmunity in mice and humans. We engineered the Fc …
A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
GL Moore, C Bautista, E Pong, DHT Nguyen, J Jacinto… - MAbs, 2011 - Taylor & Francis
… For the anti-CD16 ADCC assay, PBMCs were added at 50:1 effector to target ratio (E:… E:T
was 50:1 and incubation time was 24 h. For the anti-CD3 killing assay with T cells as effectors, E…
was 50:1 and incubation time was 24 h. For the anti-CD3 killing assay with T cells as effectors, E…
Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
SY Chu, HM Horton, E Pong, IWL Leung… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Sequestration of IgE to prevent its binding to high-affinity IgE receptor
FcεRI on basophils and mast cells is an effective therapy for allergic asthma. IgE production …
FcεRI on basophils and mast cells is an effective therapy for allergic asthma. IgE production …
Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
HM Horton, MJ Bernett, M Peipp, E Pong… - Blood, The Journal …, 2010 - ashpublications.org
… Tumor cells were labeled with 51Cr (100 μCi/106 cells), opsonized with antibodies, and
mixed with PBMCs or NK cells at an E/T ratio of 80:1 and 10:1, respectively; 51Cr release was …
mixed with PBMCs or NK cells at an E/T ratio of 80:1 and 10:1, respectively; 51Cr release was …
[HTML][HTML] A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats
GL Moore, MJ Bernett, R Rashid, EW Pong… - Methods, 2019 - Elsevier
Bispecific monoclonal antibodies can bind two protein targets simultaneously and enable
therapeutic modalities inaccessible by traditional mAbs. Bispecific formats containing a …
therapeutic modalities inaccessible by traditional mAbs. Bispecific formats containing a …
Suppression of rheumatoid arthritis B cells by XmAb5871, an anti‐CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory …
SY Chu, K Yeter, R Kotha, E Pong… - Arthritis & …, 2014 - Wiley Online Library
Objective Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents
a promising target for therapy in autoimmunity. The aim of this study was to characterize …
a promising target for therapy in autoimmunity. The aim of this study was to characterize …
[HTML][HTML] Immunotherapy with long-lived anti-CD123× anti-CD3 bispecific antibodies stimulates potent T cell-mediated killing of human AML cell lines and of CD123+ …
SY Chu, E Pong, H Chen, S Phung, EW Chan… - Blood, 2014 - Elsevier
CD123 (IL-3 receptor alpha) is highly expressed on acute myeloid leukemia stem cells and
blasts, and represents a promising target of antibody therapies for AML. Anti-CD123 …
blasts, and represents a promising target of antibody therapies for AML. Anti-CD123 …
Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
G Deng, A Chen, E Pong, YS Kim - Oncogene, 2001 - nature.com
Microsatellite instability (MSI) is caused by the dysfunction of mismatch repair genes, such
as hMLH1, hMSH2. Loss of hMLH1 expression and methylation of CpG sites in hMLH1 …
as hMLH1, hMSH2. Loss of hMLH1 expression and methylation of CpG sites in hMLH1 …