This article proposes a method to construct inflation-friendly equity strategies that offer
protection against inflation surprises. Such strategies offer stronger and more consistent inflation …

We examine factor performance during the first quarter of 2020, a period in which markets
were significantly impacted by the emergence of the Covid-19 pandemic. Certain factors like …

Immune checkpoint blockade (CPB) improves melanoma outcomes, but many patients still
do not respond. Tumor mutational burden (TMB) and tumor-infiltrating T cells are associated …

Multi-omics datasets are becoming more common, necessitating better integration methods
to realize their revolutionary potential. Here, we introduce multi-set correlation and factor …

… We thank Noël Amenc, Daniel Aguet and two anonymous referees for helpful comments
and suggestions that greatly improved the quality of this paper. …

Cancer immunotherapy with checkpoint blockade has improved survival and outcomes in
melanoma, but still a majority of patients do not respond. Both high tumor mutation burden (…

INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

The JAK–STAT signaling pathway has been implicated in mediating biologic responses
induced by many cytokines. However, cytokines that promote distinct cellular responses often …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …